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Article

Intrinsic hepatic phenotype associated with the Cyp1a2 gene as shown by cDNA expression microarray analysis of the knockout mouse.

EHP toxicogenomics : journal of the National Institute of Environmental Health Sciences - 1 Jan 2003

Smith Andrew G, Davies Reginald, Dalton Timothy P, Miller Marian L, Judah David, Riley Joan, Gant Timothy, Nebert Daniel W

Abstract excerpt

Several forms of cytochrome P450 (CYP) appear to metabolize principally pharmaceutical agents, as well as other dietary and plant chemicals. Other CYP forms have major roles in steroid, sterol, and bile acid metabolism. CYP1A2 expression is constitutively high in mouse liver and is well known for metabolizing several drugs and many procarcinogens to reactive intermediates that can cause toxicity or cancer. CYP1A2...

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PMID: 12735109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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