Article
Targeted disruption of the olfactory mucosa-specific Cyp2g1 gene: impact on acetaminophen toxicity in the lateral nasal gland, and tissue-selective effects on Cyp2a5 expression.
The Journal of pharmacology and experimental therapeutics - 1 Feb 2004
Zhuo Xiaoliang, Gu Jun, Behr Melissa J, Swiatek Pam J, Cui Huadong, Zhang Qing-Yu, Xie Yingqiu, Collins Doris N, Ding Xinxin
Abstract excerpt
CYP2G1 is a cytochrome P450 monooxygenase expressed uniquely in the olfactory mucosa (OM). We have generated Cyp2g1-null mice to identify the roles of CYP2G1 in the biology and the tissue-specific toxicity of xenobiotic compounds in the nose. Homozygous Cyp2g1-null mice are viable and fertile; they show no evidence of embryonic lethality, morphological abnormality, or developmental deficits; and they seem to have...
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