Article
Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2.
Proceedings of the National Academy of Sciences of the United States of America - 23 May 1995
Pineau T, Fernandez-Salguero P, Lee S S, McPhail T, Ward J M, Gonzalez F J
Abstract excerpt
Cytochrome P450 1A2 (CYP1A2) is a constitutively expressed hepatic enzyme that is highly conserved among mammals. This protein is primarily involved in oxidative metabolism of xenobiotics and is capable of metabolically activating numerous procarcinogens including aflatoxin B1, arylamines, hetero...
Topics
- Animals
- Animals, Newborn
- Cytochrome P-450 CYP1A2
- Cytochrome P-450 Enzyme System
- Death
- Embryo, Mammalian
- Enzyme Induction
- Exons
- Gallbladder
- Humans
- Infant, Newborn
- Liver
- Lung
- Mammals
- Mice
- Mice, Mutant Strains
- Oxidoreductases
- Phenotype