Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2.

Proceedings of the National Academy of Sciences of the United States of America - 23 May 1995

Pineau T, Fernandez-Salguero P, Lee S S, McPhail T, Ward J M, Gonzalez F J

Abstract excerpt

Cytochrome P450 1A2 (CYP1A2) is a constitutively expressed hepatic enzyme that is highly conserved among mammals. This protein is primarily involved in oxidative metabolism of xenobiotics and is capable of metabolically activating numerous procarcinogens including aflatoxin B1, arylamines, heterocyclic amine food mutagens, and polycylic aromatic hydrocarbons. Expression of CYP1A2 is induced after exposure to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 Enzyme System
Share to Exons

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Infant, Newborn

Share to Mice, Mutant Strains

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 7761462
DOI: 10.1073/pnas.92.11.5134
PMCID: PMC41863

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2.PMID 7761462Read ↗

Interpreting neonatal lethal phenotypes in mouse mutants: insights into gene function and human diseases.Semantic proximity Read ↗

Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translationSemantic proximity Read ↗

Genetic variation in the activity of a TREM2-p53 signaling axis determines oxygen-induced lung injurySemantic proximity Read ↗

Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal β-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants.Semantic proximity Read ↗

Inherited disorders of neonatal lung diseases.Semantic proximity Read ↗

Genetic variation in the activity of a TREM2-p53 signaling axis determines oxygen-induced lung injury.Semantic proximity Read ↗

Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome.Semantic proximity Read ↗

Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice.Semantic proximity Read ↗

Genome-wide association mapping of acute lung injury in neonatal inbred mice.Semantic proximity Read ↗

Conditional knockout of the mouse NADPH-cytochrome p450 reductase gene.Semantic proximity Read ↗

Cytochrome P450 knockout mice: new toxicological models.Semantic proximity Read ↗

In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.