Article
Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice.
Toxicology and applied pharmacology - 1 Sept 1998
Zaher H, Buters J T, Ward J M, Bruno M K, Lucas A M, Stern S T, Cohen S D, Gonzalez F J
Abstract excerpt
Acetaminophen (APAP) hepatotoxicity is due to its biotransformation to a reactive metabolite, N-acetyl-p-benzoquinone imine (NAPQI), that is capable of binding to cellular macromolecules. At least two forms of cytochrome P450, CYP2E1 and CYP1A2, have been implicated in this reaction in mice. To test the combined roles of CYP1A2 and CYP2E1 in an intact animal model, a double-null mouse line lacking functional...
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