Article
Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice.
Toxicology and applied pharmacology - 1 Sept 1998
Zaher H, Buters J T, Ward J M, Bruno M K, Lucas A M, Stern S T, Cohen S D, Gonzalez F J
Abstract excerpt
Acetaminophen (APAP) hepatotoxicity is due to its biotransformation to a reactive metabolite, N-acetyl-p-benzoquinone imine (NAPQI), that is capable of binding to cellular macromolecules. At least two forms of cytochrome P450, CYP2E1 and CYP1A2, have been implicated in this reaction in mice. To t...
Topics
- Acetaminophen
- Alanine Transaminase
- Analgesics, Non-Narcotic
- Animals
- Cytochrome P-450 CYP1A2
- Cytochrome P-450 CYP2E1
- DNA
- Dose-Response Relationship, Drug
- Gene Deletion
- Genotype
- Glutathione
- Kidney Tubules
- L-Iditol 2-Dehydrogenase
- Lipidoses
- Liver
- Male
- Mice
- Mice, Inbred C57BL