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Article

Role of gene knockout mice in understanding the mechanisms of chemical toxicity and carcinogenesis.

Cancer letters - 1 Sept 1999

Gonzalez F J, Kimura S

Abstract excerpt

Most chemical carcinogens require metabolic activation to electrophilic metabolites that are capable of binding to DNA and causing gene mutation. Carcinogen metabolism is carried out by large groups of xenobiotic-metabolizing enzymes that include the phase I cytochromes P450 (P450) and phase II enzymes that include various transferases. During the past 10 years, considerable attention has been focused on the role...

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Source

Identifiers

PMID: 10503904
DOI: 10.1016/s0304-3835(99)00125-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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