Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Liver-selective expression of human arylamine N-acetyltransferase NAT2 in transgenic mice.

Drug metabolism and disposition: the biological fate of chemicals - 1 May 2011

Sugamori Kim S, Brenneman Debbie, Grant Denis M

Abstract excerpt

Human arylamine N-acetyltransferase 2 (NAT2) mediates the biotransformation of arylamine drugs and procarcinogens into either innocuous or reactive DNA-damaging metabolites and is expressed predominantly in liver. Interspecies differences and incongruous results between in vitro, in vivo, and epidemiological studies make it difficult to extrapolate animal results to human risk. We have generated human NAT2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Infective Agents
Share to Antitubercular Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Arylamine N-Acetyltransferase

Share to Cytosol

Share to Mice, Transgenic

Share to Sulfamethazine

Source

Identifiers

PMID: 21317369
DOI: 10.1124/dmd.111.038216

Genes

NAT2
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Liver-selective expression of human arylamine N-acetyltransferase NAT2 in transgenic mice.PMID 21317369Read ↗

Generation and functional characterization of arylamine N-acetyltransferase Nat1/Nat2 double-knockout mice.Semantic proximity Read ↗

Systemic functional expression of N-acetyltransferase polymorphism in the F344 Nat2 congenic rat.Semantic proximity Read ↗

Pharmacogenetics of the arylamine N-acetyltransferases.Semantic proximity Read ↗

Regulation of arylamine N-acetyltransferases.Semantic proximity Read ↗

Polymorphism of human acetyltransferases.Semantic proximity Read ↗

Pharmacogenetics, Regulation and Structural Properties of the Drugmetabolizing Enzymes Arylamine N-acetyltransferases.Semantic proximity Read ↗

Human Arylamine <i>N</i> -Acetyltransferase Genes: Isolation, Chromosomal Localization, and Functional ExpressionSemantic proximity Read ↗

Polymorphisms of N-acetyltransferase genes.Semantic proximity Read ↗

Human arylamine N-acetyltransferase 2 genotype-dependent protein expression in cryopreserved human hepatocytes.Semantic proximity Read ↗

Rabbit N-acetyltransferase 2 genotyping method to investigate role of acetylation polymorphism on N- and O-acetylation of aromatic and heterocyclic amine carcinogens.Semantic proximity Read ↗

Arylamine N-acetyltransferase acetylation polymorphisms: paradigm for pharmacogenomic-guided therapy- a focused review.Semantic proximity Read ↗

ArylamineN-acetyltransferasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.