Cytochrome P450 knockout mice: new toxicological models.

doi:10.1111/j.1440-1681.1998.tb02153.x

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Article

Cytochrome P450 knockout mice: new toxicological models.

Clinical and experimental pharmacology & physiology - 1 Oct 1998

McKinnon R A, Nebert D W

Abstract excerpt

1. Despite the frenetic pace of cytochrome P450 (CYP) research, important questions remain about the possible role of xenobiotic-metabolizing CYP in development and cellular homeostasis. 2. The recent experimental development of CYP null mouse lines has provided valuable new models for addressing...

Topics

Animals
Cytochrome P-450 Enzyme System
Gene Targeting
Mice
Mice, Knockout
Mutation
Toxicity Tests
Xenobiotics

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