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Article

Cytochrome P450 knockout mice: new toxicological models.

Clinical and experimental pharmacology & physiology - 1 Oct 1998

McKinnon R A, Nebert D W

Abstract excerpt

1. Despite the frenetic pace of cytochrome P450 (CYP) research, important questions remain about the possible role of xenobiotic-metabolizing CYP in development and cellular homeostasis. 2. The recent experimental development of CYP null mouse lines has provided valuable new models for addressing these issues, as well as providing novel in vivo models to study the precise role of CYP in chemical-mediated...

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Identifiers

PMID: 9784916
DOI: 10.1111/j.1440-1681.1998.tb02153.x

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