A novel method for gene analysis of colorectal carcinomas using a crypt isolation technique.

Abstract excerpt

Genetic studies of tumor masses require relatively pure populations of tumor cells. Substantial contamination by stromal cells, however, usually prevents detailed analysis of tumor cells. To improve the accuracy of gene analysis of tumor cells, a crypt isolation technique was introduced to separate neoplastic crypts from nonneoplastic stromal cells. Thirty-five specimens of colorectal carcinomas were examined for...

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