Article
P53 mutations in primary and metastatic tumors and circulating tumor cells from colorectal carcinoma patients.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2000
Khan Z A, Jonas S K, Le-Marer N, Patel H, Wharton R Q, Tarragona A, Ivison A, Allen-Mersh T G
Abstract excerpt
Circulating tumor cells could provide a relatively noninvasive and repeatable source of information about tumor cell genotype that might influence treatment and estimation of prognosis. We developed a technique for identifying p53 mutations in tumor cells isolated from the peripheral venous blood of colorectal cancer patients and compared the prevalence and position of these mutations with multiple solid tumor...
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