Article
Molecular subtypes of colorectal cancers determined by PCR-based analysis.
Cancer science - 1 Mar 2017
Sugai Tamotsu, Eizuka Makoto, Takahashi Yayoi, Fukagawa Tomoyuki, Habano Wataru, Yamamoto Eiichiro, Akasaka Risaburo, Otuska Kouki, Matsumoto Takayuki, Suzuki Hiromu
Abstract excerpt
Tumor tissue consists of a heterogeneous cell population. The allelic imbalance (AI) ratio, determined in isolated tumor glands, is a good index of tumor heterogeneity. However, associations of the patterns of AI and microsatellite instability (MSI) development, observed in most cases of colorectal cancer (CRC), with tumor progression have not been reported previously. In this study, we examined whether CRC...
Topics
- Adult
- Aged
- Aged, 80 and over
- Colorectal Neoplasms
- DNA Methylation
- Female
- Humans
- Male
- Microsatellite Instability
- Microsatellite Repeats
- Middle Aged