Article
Evidence for genomic instability in human colonic aberrant crypt foci.
Oncogene - 18 Apr 1996
Augenlicht L H, Richards C, Corner G, Pretlow T P
Abstract excerpt
Aberrant crypt foci (ACF) are morphologically abnormal structures that can be identified in whole amounts of colonic tissue from rodents treated with colon carcinogens and from patients at risk for development of colon tumors. ACF are heterogeneous and exhibit properties, such as altered patterns of cell proliferation, the presence of dysplasia, and mutations in protooncogenes and tumor formation. In this study,...
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