Evidence for genomic instability in human colonic aberrant crypt foci.

Article

Evidence for genomic instability in human colonic aberrant crypt foci.

Oncogene - 18 Apr 1996

Augenlicht L H, Richards C, Corner G, Pretlow T P

Abstract excerpt

Aberrant crypt foci (ACF) are morphologically abnormal structures that can be identified in whole amounts of colonic tissue from rodents treated with colon carcinogens and from patients at risk for development of colon tumors. ACF are heterogeneous and exhibit properties, such as altered patterns...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Base Sequence
Chromosome Aberrations
Colonic Neoplasms
Female
Humans
Male
Middle Aged
Molecular Sequence Data
Phenotype
Polymerase Chain Reaction
Sequence Analysis, DNA

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