Detection of K-ras mutation in colonic effluent samples from patients without evidence of colorectal carcinoma.

doi:10.1093/jnci/86.13.1007

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Article

Detection of K-ras mutation in colonic effluent samples from patients without evidence of colorectal carcinoma.

Journal of the National Cancer Institute - 6 Jul 1994

Tobi M, Luo F C, Ronai Z

Abstract excerpt

BACKGROUND: K-ras gene mutation appears in more than 50% of patients with colon tumors. Both its frequency and early appearance may qualify this mutation as a potential biomarker. To enable early detection of mutant K-ras alleles, we had previously developed a sensitive polymerase chain reaction...

Topics

Adult
Aged
Base Sequence
Colon
Colorectal Neoplasms
Enema
Female
Genes, ras
Humans
Intestinal Secretions
Male
Middle Aged
Molecular Sequence Data
Mutation

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