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Article

Detection of K-ras mutation in colonic effluent samples from patients without evidence of colorectal carcinoma.

Journal of the National Cancer Institute - 6 Jul 1994

Tobi M, Luo F C, Ronai Z

Abstract excerpt

BACKGROUND: K-ras gene mutation appears in more than 50% of patients with colon tumors. Both its frequency and early appearance may qualify this mutation as a potential biomarker. To enable early detection of mutant K-ras alleles, we had previously developed a sensitive polymerase chain reaction (PCR)-based assay, i.e., enriched PCR, which enables detection of one mutant K-ras allele present within 10,000 normal...

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PMID: 8007010
DOI: 10.1093/jnci/86.13.1007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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