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Article

Analysis of SMAD4/DPC4 gene alterations in multiploid colorectal carcinomas.

Journal of gastroenterology - 1 Jul 2005

Ando Tatsuya, Sugai Tamotsu, Habano Wataru, Jiao Yu-Fei, Suzuki Kazuyuki

Abstract excerpt

BACKGROUND: Although recent animal studies have shown that SMAD4/DPC4 gene alterations are essential for late-stage intestinal tumorigenesis, the role of SMAD4/DPC4 gene alterations in primary human colorectal carcinomas is not fully understood. Therefore, we attempted to clarify the role of the SMAD4/DPC4 gene during tumor progression of colorectal carcinoma. METHODS: Differences in allelic imbalance (AI) and...

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Source

Identifiers

PMID: 16082587
DOI: 10.1007/s00535-005-1614-z

Genes

SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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