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Article

Isolation and molecular characterization of a poliovirus type 1 mutant that replicates in the spinal cords of mice.

Journal of virology - 1 Jul 1999

Jia Q, Ohka S, Iwasaki K, Tohyama K, Nomoto A

Abstract excerpt

The Mahoney strain of poliovirus type 1 (OM) is generally unable to cause paralysis in mice. We isolated a mouse-adapted mutant, PV1/OM-SA (SA), from the spinal cord of a mouse that had been intracerebrally inoculated with OM. SA showed mouse neurovirulence only with intraspinal inoculation, and the infected mice developed a flaccid paralysis, which was indistinguishable from that observed in poliovirus-sensitive...

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Identifiers

PMID: 10364356
DOI: 10.1128/JVI.73.7.6041-6047.1999
PMCID: PMC112665

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