Isolation and molecular characterization of a poliovirus type 1 mutant that replicates in the spinal cords of mice.

doi:10.1128/JVI.73.7.6041-6047.1999

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Article

Isolation and molecular characterization of a poliovirus type 1 mutant that replicates in the spinal cords of mice.

Journal of virology - 1 Jul 1999

Jia Q, Ohka S, Iwasaki K, Tohyama K, Nomoto A

Abstract excerpt

The Mahoney strain of poliovirus type 1 (OM) is generally unable to cause paralysis in mice. We isolated a mouse-adapted mutant, PV1/OM-SA (SA), from the spinal cord of a mouse that had been intracerebrally inoculated with OM. SA showed mouse neurovirulence only with intraspinal inoculation, and...

Topics

Adaptation, Physiological
Animals
Binding Sites
Cell Line
Chlorocebus aethiops
Glial Fibrillary Acidic Protein
HeLa Cells
Humans
Mice
Mice, Inbred Strains
Mice, Transgenic
Mutation
Phenotype
Poliovirus
Spinal Cord
Virus Replication

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