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Article

Evolution in a chronic RNA virus infection: selection on HTLV-I tax protein differs between healthy carriers and patients with tropical spastic paraparesis.

Journal of molecular evolution - 1 Apr 1996

Niewiesk S, Bangham C R

Abstract excerpt

HTLV-I causes T-cell leukemia and tropical spastic paraparesis (TSP) in a minority of infected people, whereas the majority remain healthy. The virus differs little in sequence between isolates but has been shown to have a quasispecies structure. Using the Nei and Gojobori algorithm, we have show...

Topics

Biological Evolution
Carrier State
Chronic Disease
DNA, Complementary
Gene Products, rex
Gene Products, tax
Genetic Variation
Genome, Viral
Human T-lymphotropic virus 1
Humans
Paraparesis, Tropical Spastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Selection, Genetic

T-Lymphocytes, Cytotoxic

Time Factors

Source

Identifiers

PMID: 8642614
DOI: 10.1007/BF02498639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8642614-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Evolution in a chronic RNA virus infection: selection on HTLV-I tax protein differs between healthy carriers and patients with tropical spastic paraparesis.PMID 8642614Read ↗

The transactivator gene of human T-cell leukemia virus type I is more variable within and between healthy carriers than patients with tropical spastic paraparesis.Semantic proximity Read ↗

Mutation rates in LTR of HTLV-1 in HAM/TSP patients and the carriers are similarly high to Tax/Rex-coding sequence.Semantic proximity Read ↗

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Polymorphisms in HTLV-1 Tax-responsive elements in HTLV-1-associated myelopathy/tropical spastic paraparesis patients are associated with reduced proviral load but not with disease progression.Semantic proximity Read ↗

Deep Sequencing Analysis of Human T Cell Lymphotropic Virus Type 1 Long Terminal Repeat 5' Region from Patients with Tropical Spastic Paraparesis/Human T Cell Lymphotropic Virus Type 1-Associated Myelopathy and Asymptomatic Carriers.Semantic proximity Read ↗

Sequence variants of human T-cell lymphotropic virus type I from patients with tropical spastic paraparesis and adult T-cell leukemia do not distinguish neurological from leukemic isolates.Semantic proximity Read ↗

The influence of human leukocyte antigen class I loci -A, -B, -C, and class II HLA-DRB1 alleles in a Brazilian HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) population and association with disease outcome and proviral loadSemantic proximity Read ↗

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