Article
Nucleotide sequence analysis of a provirus derived from an individual with tropical spastic paraparesis.
Microbial pathogenesis - 1 Apr 1990
Evangelista A, Maroushek S, Minnigan H, Larson A, Retzel E, Haase A, Gonzalez-Dunia D, McFarlin D, Mingioli E, Jacobson S
Abstract excerpt
Human T-cell lymphotropic virus type 1 (HTLV-1), the cause of inapparent infections and T-cell leukemias and lymphomas, has also been implicated in two chronic neurological diseases, tropical spastic paraparesis (TSP) and HTLV-1 associated myelopathy (HAM). We initiated a search for a neurotropic variant of HTLV-1 that might be responsible for these chronic progressive myelopathies by cloning and sequencing a...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Line
- Cloning, Molecular
- DNA, Viral
- Gene Products, env
- Genes, env
- Human T-lymphotropic virus 1
- Humans
- Molecular Sequence Data
- Mutation