Article
Lack of tax diversity for tropical spastic paraparesis/human T-cell lymphotropic virus type 1 (HTLV-I) associated myelopathy development in HTLV-I-infected subjects in São Paulo, Brazil.
Memorias do Instituto Oswaldo Cruz - 1 May 2006
Casseb J, Fukumori Lmi, Vergara Mpp, Sanabani S, Marchiori Pe, Duarte Ajs, Oliveira Acp de
Abstract excerpt
The product of human T-cell lymphotropic virus type 1 (HTLV-1) tax gene has a transactivating effect of the viral and cellular gene expression. Genetic variations in this gene have been correlated with differences in clinical outcomes. Based upon its diversity, two closely related substrains, namely tax A and tax B, have been described. The tax A substrain has been found at a higher frequency among human T-cell...
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