Article
Comparative molecular analysis of HTLV-I proviral DNA in HTLV-I infected members of a family with a discordant HTLV-I-associated myelopathy in monozygotic twins.
Journal of neurovirology - 1 Aug 2000
Nakane S, Shirabe S, Moriuchi R, Mizokami A, Furuya T, Nishiura Y, Okazaki S, Yoshizuka N, Suzuki Y, Nakamura T, Katamine S, Gojobori T, Eguchi K
Abstract excerpt
In order to elucidate the underlying mechanisms of a discordant case with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in monozygotic twins, we investigated HTLV-I tax sequences of 10 - 18 polymerase chain reaction-based clones each derived from peripheral blood mononuclear cells of the twins as well as their infected mother and an elder brother who also suffered from HAM/TSP. Sequence...
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