Article
Mutation rates in LTR of HTLV-1 in HAM/TSP patients and the carriers are similarly high to Tax/Rex-coding sequence.
Journal of neurovirology - 1 Oct 1996
Saito M, Furukawa Y, Kubota R, Usuku K, Izumo S, Osame M, Yoshida M
Abstract excerpt
The genomic sequence of human T-cell leukemia virus type 1 (HTLV-1) is highly conserved, although minor sequence variations enable classification of the isolates into several subgroups. We previously reported, however, that the Tax-coding sequence of HTLV-1 genome is highly variable in a random f...
Topics
- Base Sequence
- Carrier State
- DNA Mutational Analysis
- DNA, Viral
- Genetic Variation
- Human T-lymphotropic virus 1
- Humans
- Mutation
- Paraparesis, Tropical Spastic
- Polymerase Chain Reaction
- Repetitive Sequences, Nucleic Acid