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Article

The transactivator gene of human T-cell leukemia virus type I is more variable within and between healthy carriers than patients with tropical spastic paraparesis.

Journal of virology - 1 Oct 1994

Niewiesk S, Daenke S, Parker C E, Taylor G, Weber J, Nightingale S, Bangham C R

Abstract excerpt

Human T-cell leukemia virus type I (HTLV-1) causes T-cell leukemia and tropical spastic paraparesis (TSP) in a minority of infected people, whereas the majority remain healthy. No association between a particular HTLV-I sequence and disease manifestation has been found in previous studies. We studied here the sequence variability of the gene for the HTLV-I Tax protein, which is the dominant target antigen of the...

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Identifiers

PMID: 8084014
DOI: 10.1128/JVI.68.10.6778-6781.1994
PMCID: PMC237103

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The transactivator gene of human T-cell leukemia virus type I is more variable within and between healthy carriers than patients with tropical spastic paraparesis.PMID 8084014Read ↗

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Mutation rates in LTR of HTLV-1 in HAM/TSP patients and the carriers are similarly high to Tax/Rex-coding sequence.Semantic proximity Read ↗

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Bioinformatic analysis of the variability of Tax1 and Tax2 proteins of the human T-cell lymphotropic virus (HTLV)Semantic proximity Read ↗

HLA-G 3'-untranslated region polymorphisms are associated with HTLV-1 infection, proviral load and HTLV-associated myelopathy/tropical spastic paraparesis development.Semantic proximity Read ↗

The influence of human leukocyte antigen class I loci -A, -B, -C, and class II HLA-DRB1 alleles in a Brazilian HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) population and association with disease outcome and proviral loadSemantic proximity Read ↗

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