Article
Engraftment of W/c-kit mutant mice is determined by stem cell competition, not by increased marrow 'space'.
Experimental hematology - 1 Feb 1996
Fleishman R A
Abstract excerpt
W/c-kit mutant mice accept engraftment by small numbers of normal hematopoietic stem cells without the necessity for myeloablation. One explanation for this observation is that a deficiency of Kit receptors reduces the number of primitive hematopoietic stem cells and increases the number of available "niches" or "space" in the marrow. As a test of this model, we transplanted a series of unirradiated W mutant mice...
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