Article
Stem cell engraftment strategies.
Annals of the New York Academy of Sciences - 1 Jun 2001
Quesenberry P J, Stewart F M, Becker P, D'Hondt L, Frimberger A, Lambert J F, Colvin G A, Miller C, Heyes C, Abedi M, Dooner M, Carlson J, Reilly J, McAuliffe C, Stencel K, Ballen K, Emmons R, Doyle P, Zhong S, Wang H, Habibian H
Abstract excerpt
The donor stem cell phenotype and host microenvironment determine the outcome of a stem cell transplant. In a series of transplant studies in syngeneic male to female or congenic Ly5.1/Ly5.2 models in which hosts have received no or minimal irradiation (100 cGy), evidence overwhelmingly supports the concept that syngeneic engraftment is determined by stem cell competition. These approaches can be extended to H-2...
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