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Article

Rescue of lethal c-KitW/W mice by erythropoietin.

Blood - 15 Sept 2004

Waskow Claudia, Terszowski Grzegorz, Costa Céline, Gassmann Max, Rodewald Hans-Reimer

Abstract excerpt

Homozygous natural white-spotted (W) mutations in the gene encoding the receptor tyrosine kinase c-Kit are associated with hypoplastic bone marrow, severe macrocytic anemia, and lethality during early postnatal life. c-Kit(W/W) mice can be rescued by wild-type hematopoietic stem cells (HSCs), but it is not known whether the lethality of c-Kit(W/W) mice is the result of HSC failure or defects specific for...

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Identifiers

PMID: 15178584
DOI: 10.1182/blood-2004-04-1247

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EPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Rescue of lethal c-KitW/W mice by erythropoietin.PMID 15178584Read ↗

Viable c-Kit(W/W) mutants reveal pivotal role for c-kit in the maintenance of lymphopoiesis.Semantic proximity Read ↗

Age-dependent amelioration of hypoplastic anemia in Ws/Ws rats with a small deletion at the kinase domain of c-kit.Semantic proximity Read ↗

The murine W/c-kit and Steel loci and the control of hematopoiesis.Semantic proximity Read ↗

A mouse model for an erythropoietin-deficiency anemia.Semantic proximity Read ↗

Combined action of c-kit and erythropoietin on erythroid progenitor cells.Semantic proximity Read ↗

W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor.Semantic proximity Read ↗

Erythropoietin receptor signaling regulates both erythropoiesis and megakaryopoiesis in vivo.Semantic proximity Read ↗

Induction of the murine "W phenotype" in long-term cultures of human cord blood cells by c-kit antisense oligomers.Semantic proximity Read ↗

Heterozygous kit mutants with little or no apparent anemia exhibit large defects in overall hematopoietic stem cell function.Semantic proximity Read ↗

A mouse model of adult-onset anaemia due to erythropoietin deficiency.Semantic proximity Read ↗

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor.Semantic proximity Read ↗

Mouse hematopoietic stem cells and the interaction of c-kit receptor and steel factor.Semantic proximity Read ↗

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