Article
Temporal replacement of donor erythrocytes and leukocytes in nonanemic W44J/W44J and severely anemic W/Wv mice.
Blood - 15 Sept 1991
Barker J E, Greer J, Bacon S, Compton S T
Abstract excerpt
The dominant white spotting, W, locus in the mouse encodes Kit, a receptor molecule with cytosolic tyrosine kinase activity. Mutations in Kit deplete hematopoietic cells by an as yet unknown mechanism, but one that presumably affects the early progenitors of all cell lineages. To examine cell lineage-specific changes caused by different W mutations, we injected genetically marked normal marrow cells into mutant...
Topics
- Anemia, Macrocytic
- Animals
- Bone Marrow Transplantation
- Erythrocytes
- Erythroid Precursor Cells
- Erythropoiesis
- Genotype
- Hematopoiesis
- Leukocytes
- Mice
- Mutation