Article
Kit regulates HSC engraftment across the human-mouse species barrier.
Cell stem cell - 7 Aug 2014
Cosgun Kadriye Nehir, Rahmig Susann, Mende Nicole, Reinke Sören, Hauber Ilona, Schäfer Carola, Petzold Anke, Weisbach Henry, Heidkamp Gordon, Purbojo Ariawan, Cesnjevar Robert, Platz Alexander, Bornhäuser Martin, Schmitz Marc, Dudziak Diana, Hauber Joachim, Kirberg Jörg, Waskow Claudia
Abstract excerpt
In-depth analysis of the cellular and molecular mechanisms regulating human HSC function will require a surrogate host that supports robust maintenance of transplanted human HSCs in vivo, but the currently available options are problematic. Previously we showed that mutations in the Kit receptor enhance engraftment of transplanted HSCs in the mouse. To generate an improved model for human HSC transplantation and...
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