Article
Induction of the murine "W phenotype" in long-term cultures of human cord blood cells by c-kit antisense oligomers.
Journal of cellular physiology - 1 Oct 1993
Migliaccio A R, Migliaccio G, Mancini G, Ratajczak M, Gewirtz A M, Adamson J W
Abstract excerpt
The murine white (W) spotting locus is the site of the c-kit gene and encodes a tyrosine kinase receptor while the complementary Steel (Sl) locus encodes its ligand. Mutations at either locus have profound effects on hematopoiesis, particularly erythroid and mast cell proliferation. We added c-ki...
Topics
- Animals
- Antisense Elements (Genetics)
- Base Sequence
- Blood Cells
- Cell Count
- Cells, Cultured
- Fetal Blood
- Gene Expression Regulation
- Hematopoietic Cell Growth Factors
- Hematopoietic Stem Cells
- Humans
- Interleukin-3
- Mice
- Molecular Sequence Data
- Oligonucleotide Probes
- Oligonucleotides, Antisense
- Phenotype
- Proto-Oncogene Proteins