Article
Induction of the murine "W phenotype" in long-term cultures of human cord blood cells by c-kit antisense oligomers.
Journal of cellular physiology - 1 Oct 1993
Migliaccio A R, Migliaccio G, Mancini G, Ratajczak M, Gewirtz A M, Adamson J W
Abstract excerpt
The murine white (W) spotting locus is the site of the c-kit gene and encodes a tyrosine kinase receptor while the complementary Steel (Sl) locus encodes its ligand. Mutations at either locus have profound effects on hematopoiesis, particularly erythroid and mast cell proliferation. We added c-kit antisense oligonucleotides to long-term suspension cultures of enriched human umbilical cord progenitor cells. This...
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