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Article

Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM.

Diabetes - 1 Mar 1998

Ohta Y, Tanizawa Y, Inoue H, Hosaka T, Ueda K, Matsutani A, Repunte V P, Yamada M, Kurachi Y, Bryan J, Aguilar-Bryan L, Permutt M A, Oka Y

Abstract excerpt

The sulfonylurea receptor 1 (SUR1) is an essential regulatory subunit of the beta-cell ATP-sensitive K+ channel (K[ATP]). The possible role of SUR1 gene mutation(s) in the development of NIDDM remains controversial as both a positive association and negative linkage results have been reported. Therefore, we examined the SUR1 gene at the single nucleotide level with single strand conformation polymorphism analysis...

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Identifiers

PMID: 9519757
DOI: 10.2337/diabetes.47.3.476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM.PMID 9519757Read ↗

Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians.Semantic proximity Read ↗

Genetic analysis of Japanese patients with persistent hyperinsulinemic hypoglycemia of infancy: nucleotide-binding fold-2 mutation impairs cooperative binding of adenine nucleotides to sulfonylurea receptor 1.Semantic proximity Read ↗

Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in while Caucasian subjects or evidence of abnormal function when expressed in vitro.Semantic proximity Read ↗

Hyperinsulinism-Causing Mutations Cause Multiple Molecular Defects in SUR1 NBD1.Semantic proximity Read ↗

Sulfonylurea receptor -1 (SUR1): genetic and metabolic evidences for a role in the susceptibility to type 2 diabetes mellitus.Semantic proximity Read ↗

Review. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator.Semantic proximity Read ↗

An abundant, truncated human sulfonylurea receptor 1 splice variant has prodiabetic properties and impairs sulfonylurea action.Semantic proximity Read ↗

A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes.Semantic proximity Read ↗

A universally conserved residue in the SUR1 subunit of the KATP channel is essential for translating nucleotide binding at SUR1 into channel opening.Semantic proximity Read ↗

Potassium channel regulation.Semantic proximity Read ↗

Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1Semantic proximity Read ↗

A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults.Semantic proximity Read ↗

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