Article
Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM.
Diabetes - 1 Mar 1998
Ohta Y, Tanizawa Y, Inoue H, Hosaka T, Ueda K, Matsutani A, Repunte V P, Yamada M, Kurachi Y, Bryan J, Aguilar-Bryan L, Permutt M A, Oka Y
Abstract excerpt
The sulfonylurea receptor 1 (SUR1) is an essential regulatory subunit of the beta-cell ATP-sensitive K+ channel (K[ATP]). The possible role of SUR1 gene mutation(s) in the development of NIDDM remains controversial as both a positive association and negative linkage results have been reported. Th...
Topics
- ATP-Binding Cassette Transporters
- Adenosine Triphosphate
- Adult
- Aged
- Alleles
- Animals
- COS Cells
- Cohort Studies
- Diabetes Mellitus, Type 2
- Dose-Response Relationship, Drug
- Female
- Gene Expression
- Gene Frequency
- Humans