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Article

KCNJ11, ABCC8 and TCF7L2 polymorphisms and the response to sulfonylurea treatment in patients with type 2 diabetes: a bioinformatics assessment.

BMC medical genetics - 6 Jun 2017

Song Jingwen, Yang Yunzhong, Mauvais-Jarvis Franck, Wang Yu-Ping, Niu Tianhua

Abstract excerpt

BACKGROUND: Type 2 diabetes (T2D) is a worldwide epidemic with considerable health and economic consequences. Sulfonylureas are widely used drugs for the treatment of patients with T2D. KCNJ11 and ABCC8 encode the Kir6.2 (pore-forming subunit) and SUR1 (regulatory subunit that binds to sulfonylurea) of pancreatic β cell KATP channel respectively with a critical role in insulin secretion and glucose homeostasis....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Potassium Channels, Inwardly Rectifying

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Source

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Identifiers

PMID: 28587604
DOI: 10.1186/s12881-017-0422-7
PMCID: PMC5461698

Genes

ABCC8
KCNJ11

Variants

rs5219
rs5219
rs5219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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