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Article

Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1

1 Oct 2000

Abstract excerpt

ATP-sensitive potassium channels play a major role in linking metabolic signals to the exocytosis of insulin in the pancreatic beta cell. These channels consist of two types of protein subunit: the sulfonylurea receptor SUR1 and the inward rectifying potassium channel Kir6.2. Mutations in the genes encoding these proteins are the most common cause of congenital hyperinsulinism (CHI). Since 1973, we have followed...

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PMID: 11018078
DOI: 10.1172/jci9804

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Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1PMID 11018078Read ↗

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