Article
Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene.
Diabetes - 1 Apr 1998
Hansen T, Echwald S M, Hansen L, Møller A M, Almind K, Clausen J O, Urhammer S A, Inoue H, Ferrer J, Bryan J, Aguilar-Bryan L, Permutt M A, Pedersen O
Abstract excerpt
The high-affinity sulfonylurea receptor (SUR1) is, as a subunit of the ATP-sensitive potassium channel, an important regulator of insulin secretion in the pancreatic beta-cell. The aim of this study was to examine if genetic variability of the SUR1 gene was associated with NIDDM or altered pancreatic beta-cell function. Mutational analysis of all the 39 SUR1 exons, including intron-exon boundaries, in 63 NIDDM...
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