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Article

Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene.

Diabetes - 1 Apr 1998

Hansen T, Echwald S M, Hansen L, Møller A M, Almind K, Clausen J O, Urhammer S A, Inoue H, Ferrer J, Bryan J, Aguilar-Bryan L, Permutt M A, Pedersen O

Abstract excerpt

The high-affinity sulfonylurea receptor (SUR1) is, as a subunit of the ATP-sensitive potassium channel, an important regulator of insulin secretion in the pancreatic beta-cell. The aim of this study was to examine if genetic variability of the SUR1 gene was associated with NIDDM or altered pancre...

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Identifiers

PMID: 9568693
DOI: 10.2337/diabetes.47.4.598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9568693-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene.PMID 9568693Read ↗

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Clinical and Molecular Characterization of a Dominant Form of Congenital Hyperinsulinism Caused by a Mutation in the High-Affinity Sulfonylurea ReceptorSemantic proximity Read ↗

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