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Article

Metabolic control in type 2 diabetes is associated with sulfonylurea receptor-1 (SUR-1) but not with KCNJ11 polymorphisms.

Archives of medical research - 1 Jul 2009

Nikolac Nora, Simundic Ana-Maria, Katalinic Darko, Topic Elizabeta, Cipak Andrea, Zjacic Rotkvic Vanja

Abstract excerpt

BACKGROUND AND AIMS: Sulfonylureas are hypoglycemic agents used for promotion of insulin secretion in type 2 diabetics (T2D). They bind to sulfonylurea receptor-1 (SUR-1), which is a functional subunit of the ATP-sensitive potassium channel (K(ATP)). The other component of the potassium channel is Kir6.2, encoded by gene KCNJ11. Polymorphisms in these genes may lead to modulated response to sulfonylurea therapy....

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Topics

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Share to ATP-Binding Cassette Transporters
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose

Share to Glycated Hemoglobin

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Share to Potassium Channels, Inwardly Rectifying

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Source

Identifiers

PMID: 19766903
DOI: 10.1016/j.arcmed.2009.06.006

Genes

KCNJ11
AGA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Metabolic control in type 2 diabetes is associated with sulfonylurea receptor-1 (SUR-1) but not with KCNJ11 polymorphisms.PMID 19766903Read ↗

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