Article
Sequence variants in the pancreatic islet beta-cell inwardly rectifying K+ channel Kir6.2 (Bir) gene: identification and lack of role in Caucasian patients with NIDDM.
Diabetes - 1 Mar 1997
Inoue H, Ferrer J, Warren-Perry M, Zhang Y, Millns H, Turner R C, Elbein S C, Hampe C L, Suarez B K, Inagaki N, Seino S, Permutt M A
Abstract excerpt
Signals derived from the metabolism of glucose in pancreatic beta-cells lead to insulin secretion via the closure of ATP-sensitive K+ channels (KATP). The cloning of the gene encoding the beta-cell inward rectifier Kir6.2 (Bir), a subunit of the beta-cell KATP channel, provided the opportunity to...
Topics
- DNA Primers
- DNA Restriction Enzymes
- Diabetes Mellitus, Type 2
- Exons
- Genetic Variation
- Genotype
- Humans
- Insulin
- Insulin Secretion
- Islets of Langerhans
- Point Mutation
- Polymorphism, Restriction Fragment Length
- Polymorphism, Single-Stranded Conformational