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Article

Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53).

Diabetic medicine : a journal of the British Diabetic Association - 1 Mar 2001

Gloyn A L, Hashim Y, Ashcroft S J, Ashfield R, Wiltshire S, Turner R C

Abstract excerpt

AIMS: The beta-cell ATP-sensitive potassium channel consists of two subunits, SUR1 and Kir6.2. Population association studies have shown that three variants in SUR1 and one in Kir6.2 are associated with Type 2 diabetes. These polymorphisms do not result in a functional change or affect splicing, suggesting that they could be in linkage disequilibrium with a pathogenic mutation. The present study aimed firstly to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11318841
DOI: 10.1046/j.1464-5491.2001.00449.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53).PMID 11318841Read ↗

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Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in while Caucasian subjects or evidence of abnormal function when expressed in vitro.Semantic proximity Read ↗

Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study.Semantic proximity Read ↗

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.Semantic proximity Read ↗

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Effects of single nucleotide polymorphisms in K(ATP) channel genes on type 2 diabetes in a Turkish population.Semantic proximity Read ↗

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Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetesSemantic proximity Read ↗

Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians.Semantic proximity Read ↗

Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene.Semantic proximity Read ↗

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