Article
Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation of allelic variants of human cytochrome P450 CYP2D6 gene.
Human molecular genetics - 1 Dec 1995
Steen V M, Molven A, Aarskog N K, Gulbrandsen A K
Abstract excerpt
The cytochrome P450 enzyme debrisoquine 4-hydroxylase (CYP2D6) metabolizes many different classes of commonly used drugs. In Caucasian populations, 5-10% are classified as poor metabolizers (PM) due to autosomal recessive inheritance of two mutant CYP2D6 null alleles. In contrast, up to 5% may de...
Topics
- Alleles
- Base Sequence
- Chromosome Mapping
- Crossing Over, Genetic
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- DNA
- Genetic Variation
- Humans
- Mixed Function Oxygenases
- Molecular Sequence Data
- Repetitive Sequences, Nucleic Acid
- Sequence Deletion
- Sequence Homology, Nucleic Acid