Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.

Article

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.

American journal of human genetics - 1 Feb 1997

Sachse C, Brockmöller J, Bauer S, Roots I

Abstract excerpt

Cytochrome P450 2D6 (CYP2D6) metabolizes many important drugs. CYP2D6 activity ranges from complete deficiency to ultrafast metabolism, depending on at least 16 different known alleles. Their frequencies were determined in 589 unrelated German volunteers and correlated with enzyme activity measur...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Cytochrome P-450 CYP2D6
Debrisoquin
Dextromethorphan
Female
Genetic Heterogeneity
Genetic Linkage
Genetic Variation
Genotype
Humans
Male
Middle Aged
Multigene Family
Mutation
Phenotype

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