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Article

Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis.

The Journal of pharmacology and experimental therapeutics - 1 Jul 1995

Dahl M L, Johansson I, Bertilsson L, Ingelman-Sundberg M, Sjöqvist F

Abstract excerpt

Hydroxylation of debrisoquine, catalyzed by the cytochrome P450 CYP2D6 exhibits genetic polymorphism, with large inter-individual differences in metabolic capacity. About 7% of Caucasians carry deficient CYP2D6 alleles and lack the CYP2D6 enzyme (poor metabolizers). We have shown in two Swedish families, individuals carrying duplicated or amplified functional CYP2D6L-genes (CYP2D6L2), causing the opposite...

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PMID: 7616439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis.PMID 7616439Read ↗

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