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Article

Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis.

The Journal of pharmacology and experimental therapeutics - 1 Jul 1995

Dahl M L, Johansson I, Bertilsson L, Ingelman-Sundberg M, Sjöqvist F

Abstract excerpt

Hydroxylation of debrisoquine, catalyzed by the cytochrome P450 CYP2D6 exhibits genetic polymorphism, with large inter-individual differences in metabolic capacity. About 7% of Caucasians carry deficient CYP2D6 alleles and lack the CYP2D6 enzyme (poor metabolizers). We have shown in two Swedish families, individuals carrying duplicated or amplified functional CYP2D6L-genes (CYP2D6L2), causing the opposite...

Topics

Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Debrisoquin
Gene Amplification
Genetics, Population
Haplotypes
Heterozygote
Homozygote
Humans
Hydroxylation
Mixed Function Oxygenases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multigene Family

Phenotype

Sweden

Source

Identifiers

PMID: 7616439

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7616439-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis.PMID 7616439Read ↗

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