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Article

PCR-based genotyping for duplicated and deleted CYP2D6 genes.

Pharmacogenetics - 1 Aug 1996

Johansson I, Lundqvist E, Dahl M L, Ingelman-Sundberg M

Abstract excerpt

The debrisoquine hydroxylase (CYP2D6), which metabolizes more than 30 different drugs, is highly polymorphic. In subjects having either very low or very high enzyme activity, drug therapy at recommended doses using CYP2D6 substrates may lead to either increased risk of side effects or therapeutic failure. We here describe PCR-based methods for detection of alleles having either duplicated, multiduplicated or...

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PMID: 8873221
DOI: 10.1097/00008571-199608000-00008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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