Inhibition of debrisoquine hydroxylation with quinidine in subjects with three or more functional CYP2D6 genes.

doi:10.1046/j.1365-2125.2000.00120.x

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Article

Inhibition of debrisoquine hydroxylation with quinidine in subjects with three or more functional CYP2D6 genes.

British journal of clinical pharmacology - 1 Feb 2000

Dalén P, Dahl M, Andersson K, Bertilsson L

Abstract excerpt

AIMS: To study whether the CYP2D6 capacity in ultrarapid metabolizers of debrisoquine due to duplication/multiduplication of a functional CYP2D6 gene, can be 'normalised' by low doses of the CYP2D6 inhibitor quinidine and whether this is dose-dependent. METHODS: Five ultrarapid metabolizers of debrisoquine with 3, 4 or 13 functional CYP2D6 genes were given single oral doses of 5, 10, 20, 40, 80 and 160 mg...

Topics

Administration, Oral
Adult
Alleles
Chromatography, High Pressure Liquid
Cytochrome P-450 CYP2D6
Cytochrome P-450 CYP2D6 Inhibitors
Debrisoquin
Dose-Response Relationship, Drug
Enzyme Inhibitors
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Dosage

Genotype

Humans

Hydroxylation

Male

Quinidine

Source

Open in PubMed Open full text

Identifiers

PMID: 10671914
DOI: 10.1046/j.1365-2125.2000.00120.x
PMCID: PMC2014903

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