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Article

Inhibition of debrisoquine hydroxylation with quinidine in subjects with three or more functional CYP2D6 genes.

British journal of clinical pharmacology - 1 Feb 2000

Dalén P, Dahl M, Andersson K, Bertilsson L

Abstract excerpt

AIMS: To study whether the CYP2D6 capacity in ultrarapid metabolizers of debrisoquine due to duplication/multiduplication of a functional CYP2D6 gene, can be 'normalised' by low doses of the CYP2D6 inhibitor quinidine and whether this is dose-dependent. METHODS: Five ultrarapid metabolizers of debrisoquine with 3, 4 or 13 functional CYP2D6 genes were given single oral doses of 5, 10, 20, 40, 80 and 160 mg...

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Source

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Identifiers

PMID: 10671914
DOI: 10.1046/j.1365-2125.2000.00120.x
PMCID: PMC2014903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of debrisoquine hydroxylation with quinidine in subjects with three or more functional CYP2D6 genes.PMID 10671914Read ↗

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