Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ultrarapid drug metabolism: PCR-based detection of CYP2D6 gene duplication.

Clinical chemistry - 1 May 1998

Steijns L S, Van Der Weide J

Abstract excerpt

The enzyme debrisoquine 4-hydroxylase (CYP2D6), which metabolizes many widely used drugs, is highly polymorphic. The activity of the enzyme ranges between subjects from ultrafast to a complete absence. Therefore, metabolic capacity varies, producing intersubject differences in therapeutic efficacy and side effects at standard recommended doses. Up to 7% of Caucasians may demonstrate ultrarapid drug metabolism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 CYP2D6
Share to Genotype
Share to Mental Disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Multigene Family

Share to Polymerase Chain Reaction

Share to White People

Source

Identifiers

PMID: 9590361

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ultrarapid drug metabolism: PCR-based detection of CYP2D6 gene duplication.PMID 9590361Read ↗

Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events.Semantic proximity Read ↗

Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.Semantic proximity Read ↗

PCR-based genotyping for duplicated and deleted CYP2D6 genes.Semantic proximity Read ↗

Ultrarapid metabolizers of debrisoquine: characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene.Semantic proximity Read ↗

Ten percent of North Spanish individuals carry duplicated or triplicated CYP2D6 genes associated with ultrarapid metabolism of debrisoquine.Semantic proximity Read ↗

Pharmacogenetics of cytochrome P4502D6: genetic background and clinical implicationSemantic proximity Read ↗

A novel simple method for determining CYP2D6 gene copy number and identifying allele(s) with duplication/multiplication.Semantic proximity Read ↗

[Prevalence of ultraextensive drug metabolizers in Croatian population--long-PCR based detection of amplified CYP2D6 gene].Semantic proximity Read ↗

Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry.Semantic proximity Read ↗

Long-read sequencing of CYP2D6 may improve psychotropic prescribing and treatment outcomes: A systematic review and meta-analysis.Semantic proximity Read ↗

Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles.Semantic proximity Read ↗

Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.