Article
Ultrarapid drug metabolism: PCR-based detection of CYP2D6 gene duplication.
Clinical chemistry - 1 May 1998
Steijns L S, Van Der Weide J
Abstract excerpt
The enzyme debrisoquine 4-hydroxylase (CYP2D6), which metabolizes many widely used drugs, is highly polymorphic. The activity of the enzyme ranges between subjects from ultrafast to a complete absence. Therefore, metabolic capacity varies, producing intersubject differences in therapeutic efficac...
Topics
- Cytochrome P-450 CYP2D6
- Female
- Genotype
- Humans
- Male
- Mental Disorders
- Middle Aged
- Multigene Family
- Polymerase Chain Reaction
- White People