Article
Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.
Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 1993
Johansson I, Lundqvist E, Bertilsson L, Dahl M L, Sjöqvist F, Ingelman-Sundberg M
Abstract excerpt
Deficient hydroxylation of debrisoquine is an autosomal recessive trait that affects approximately 7% of the Caucasian population. These individuals (poor metabolizers) carry deficient CYP2D6 gene variants and have an impaired metabolism of severely commonly used drugs. The opposite phenomenon also exists, and certain individuals metabolize the drugs very rapidly, resulting in subtherapeutic plasma concentrations...
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