Article
Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.
Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 1993
Johansson I, Lundqvist E, Bertilsson L, Dahl M L, Sjöqvist F, Ingelman-Sundberg M
Abstract excerpt
Deficient hydroxylation of debrisoquine is an autosomal recessive trait that affects approximately 7% of the Caucasian population. These individuals (poor metabolizers) carry deficient CYP2D6 gene variants and have an impaired metabolism of severely commonly used drugs. The opposite phenomenon al...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- DNA Primers
- Debrisoquin
- Exons
- Female
- Gene Amplification
- Genetic Variation
- Genotype
- Hominidae
- Humans