Evidence for three tumor suppressor loci on chromosome 9p involved in melanoma development.

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Article

Evidence for three tumor suppressor loci on chromosome 9p involved in melanoma development.

Cancer research - 1 Feb 2001

Pollock P M, Welch J, Hayward N K

Abstract excerpt

Cytogenetic and loss of heterozygosity (LOH) studies have long indicated the presence of a tumor suppressor gene (TSG) on 9p involved in the development of melanoma. Although LOH at 9p has been reported in approximately 60% of melanoma tumors, only 5-10% of these tumors have been shown to carry CDKN2A mutations, raising the possibility that another TSG involved in melanoma maps to chromosome 9p. To investigate...

Topics

Chromosome Mapping
Chromosomes, Human, Pair 9
Genes, Tumor Suppressor
Genes, p16
Homozygote
Humans
Loss of Heterozygosity
Melanoma
Microsatellite Repeats
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Skin Neoplasms

Source

Open in PubMed

Identifiers

PMID: 11221846

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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