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Article

Mutational analysis of the p16 family cyclin-dependent kinase inhibitors p15INK4b and p18INK4c in tumor-derived cell lines and primary tumors.

Oncogene - 18 Jan 1996

Zariwala M, Liu E, Xiong Y

Abstract excerpt

The growth suppressing activity of the retinoblastoma suspectibility gene product, pRb, is down regulated by cyclin-dependent kinases 4 and 6 (CDK4 and CDK6) whose kinase activity is negatively regulated by CDK inhibitors of the p16 family. We have examined the genomic status of two recently isolated p16-related CDK inhibitors, p15 and p18, in 15 normal and 73 tumor-derived cell lines established from 23...

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Source

Identifiers

PMID: 8570224

Genes

CDK4
CDK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutational analysis of the p16 family cyclin-dependent kinase inhibitors p15INK4b and p18INK4c in tumor-derived cell lines and primary tumors.PMID 8570224Read ↗

Lack of mutation in the cyclin-dependent kinase inhibitor, p19INK4d, in tumor-derived cell lines and primary tumors.Semantic proximity Read ↗

Role of the Cyclin-Dependent Kinase 4 and 6 Inhibitor Gene Family p15, p16, p18 and p19 in Leukemia and LymphomaSemantic proximity Read ↗

Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A, and p18 genes in acute lymphoblastic leukemia of childhood.Semantic proximity Read ↗

Analysis of cyclin-dependent kinase inhibitor genes (CDKN2A, CDKN2B, andCDKN2C) in childhood rhabdomyosarcomaSemantic proximity Read ↗

Expression of the cyclin-dependent kinase inhibitors p16INK4, p15INK4B and p21WAF1/CIP1 in human breast cancer.Semantic proximity Read ↗

Disruption of the cyclin D/cyclin-dependent kinase/INK4/retinoblastoma protein regulatory pathway in human neuroblastoma.Semantic proximity Read ↗

Aberrations of p16Ink4 and retinoblastoma tumour-suppressor genes occur in distinct sub-sets of human cancer cell lines.Semantic proximity Read ↗

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Absence of p18 mutations or deletions in lymphoid malignancies.Semantic proximity Read ↗

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition.Semantic proximity Read ↗

Genetic and epigenetic alterations of the cyclin-dependent kinase inhibitors p15INK4b and p16INK4a in human thyroid carcinoma cell lines and primary thyroid carcinomasSemantic proximity Read ↗

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