Article
Mutational analysis of the p16 family cyclin-dependent kinase inhibitors p15INK4b and p18INK4c in tumor-derived cell lines and primary tumors.
Oncogene - 18 Jan 1996
Zariwala M, Liu E, Xiong Y
Abstract excerpt
The growth suppressing activity of the retinoblastoma suspectibility gene product, pRb, is down regulated by cyclin-dependent kinases 4 and 6 (CDK4 and CDK6) whose kinase activity is negatively regulated by CDK inhibitors of the p16 family. We have examined the genomic status of two recently isol...
Topics
- Amino Acid Sequence
- Base Sequence
- Carrier Proteins
- Cell Cycle Proteins
- Cyclin-Dependent Kinase Inhibitor p15
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinase Inhibitor p18
- Enzyme Inhibitors
- Humans
- Molecular Sequence Data
- Mutation
- Neoplasms
- Protein Kinase Inhibitors
- Tumor Cells, Cultured
- Tumor Suppressor Proteins