Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6.

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Article

Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6.

Cancer research - 1 Feb 1999

Noh S J, Li Y, Xiong Y, Guan K L

Abstract excerpt

Members of the INK4 family of cyclin-dependent kinase (CDK) inhibitors specifically bind and inhibit the G1-specific CDK molecules CDK4 and CDK6. One of the INK4 molecules, p16, is also known as multiple tumor suppressor and has been found to be mutated or deleted in various tumors and cell lines...

Topics

Amino Acid Sequence
Binding Sites
Binding, Competitive
Carrier Proteins
Cell Cycle
Cell Cycle Proteins
Cell Division
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase 6
Cyclin-Dependent Kinase Inhibitor p18
Cyclin-Dependent Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Enzyme Inhibitors

G1 Phase

Humans

Kinetics

Molecular Sequence Data

Mutagenesis

Mutation

Source

Open in PubMed

Identifiers

PMID: 9973200

Genes

CDK6
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9973200-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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