Article
Absence of p18 mutations or deletions in lymphoid malignancies.
Leukemia - 1 Feb 1996
Otsuki T, Jaffe E S, Wellmann A, Kumar S, Condron K S, Raffeld M
Abstract excerpt
p18 is a recently described cyclin-dependent kinase inhibitor (CDK-I) wih homology to p16 and p15. The latter two CDK-Is have been implicated as possible tumor suppressor genes in a wide variety of human tumors, including hematological malignancies. Because of p18's structural and functional homo...
Topics
- Base Sequence
- Carrier Proteins
- Chromosomes, Human, Pair 1
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinases
- Gene Deletion
- Genes, Tumor Suppressor
- Humans
- Leukemia, Lymphoid
- Lymphoma
- Molecular Sequence Data
- Mutation
- Neoplasm Proteins
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Sequence Homology, Nucleic Acid
