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Article

Alterations of the <i>p16<sup>ink4a</sup></i> gene in resected nonsmall cell lung tumors and exfoliated cells within sputum

31 Jan 2002

Abstract excerpt

Recently, we reported that p16 protein expression was nondetectable in 49.5% of 107 resected nonsmall cell lung cancers (NSCLCs), suggesting that the p16(INK4a) gene is frequently inactivated in primary NSCLC. To identify the molecular basis for this p16 immunohistochemical negativity further, we performed a genetic and epigenetic study of p16(INK4a) status in a series of 115 NSCLC samples parallel to the...

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PMID: 11920642
DOI: 10.1002/ijc.10262

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