Article
Multiple types of aberrations in thep16 (INK4a) and thep15(INK4b) genes in 30 esophageal squamous-cell-carcinoma cell lines
7 Feb 1997
Abstract excerpt
To determine the role and mode of inactivation of the p16 and p15 genes in human esophageal tumors, we examined alterations and expression of the alpha and beta forms of the p16 gene, 5' CpG island methylation of p16 exon 1 alpha, and alterations of the p15 gene in 30 esophageal squamous-cell-carcinoma cell lines. Of 30 such cell lines examined, 28 (93%) showed aberrations of the alpha form of the p16 gene: 18...
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