Article
Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A, and p18 genes in acute lymphoblastic leukemia of childhood.
Blood - 15 Jul 1995
Takeuchi S, Bartram C R, Seriu T, Miller C W, Tobler A, Janssen J W, Reiter A, Ludwig W D, Zimmermann M, Schwaller J
Abstract excerpt
A newly recognized family of proteins that inhibit cyclin-dependent kinases (CDKs) termed cyclin-dependent kinase inhibitors (CDKI) have an important role in regulation of cell-cycle progression. A subfamily of these CDKIs (p15INK4B/MTS2, p16INK4/MTS1, and p18) have a high degree of structural an...
Topics
- Age Factors
- Base Sequence
- Carrier Proteins
- Cell Cycle Proteins
- Child
- Child, Preschool
- Chromosomes, Human, Pair 9
- Cyclin-Dependent Kinase Inhibitor p15
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinase Inhibitor p18
- Cyclin-Dependent Kinases
- DNA Mutational Analysis
- DNA, Neoplasm