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Article

Tethered Sir3p nucleates silencing at telomeres and internal loci in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 May 1996

Lustig A J, Liu C, Zhang C, Hanish J P

Abstract excerpt

Rap1p binds to sites embedded within the Saccharomyces cerevisiae telomeric TG1-3 tract. Previous studies have led to the hypothesis that Rap1p may recruit Sir3p and Sir3p-associating factors to the telomere. To test this, we tethered Sir3p adjacent to the telomere via LexA binding sites in the rap1-17 mutant that truncates the Rap1p C-terminal 165 amino acids thought to contain sites for Sir3p association....

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Identifiers

PMID: 8628316
DOI: 10.1128/MCB.16.5.2483
PMCID: PMC231237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tethered Sir3p nucleates silencing at telomeres and internal loci in Saccharomyces cerevisiae.PMID 8628316Read ↗

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