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Article

Restoration of silencing in Saccharomyces cerevisiae by tethering of a novel Sir2-interacting protein, Esc8.

Genetics - 1 Oct 2002

Cuperus Guido, Shore David

Abstract excerpt

We previously described two classes of SIR2 mutations specifically defective in either telomeric/HM silencing (class I) or rDNA silencing (class II) in S. cerevisiae. Here we report the identification of genes whose protein products, when either overexpressed or directly tethered to the locus in question, can establish silencing in SIR2 class I mutants. Elevated dosage of SCS2, previously implicated as a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Silent Information Regulator Proteins, Saccharomyces cerevisiae

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Identifiers

PMID: 12399377
DOI: 10.1093/genetics/162.2.633
PMCID: PMC1462306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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