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Article

Nuclear organization and transcriptional silencing in yeast.

Experientia - 15 Dec 1996

Gotta M, Gasser S M

Abstract excerpt

Transcriptional repression at the yeast silent mating type loci requires the formation of a nucleoprotein complex at specific cis-acting elements called silencers, which in turn promotes the binding of a histone-associated Sir-protein complex to adjacent chromatin. A similar mechanism of long-range transcriptional repression appears to function near telomeric repeat sequences, where it has been demonstrated that...

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PMID: 8988257
DOI: 10.1007/BF01952113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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Nuclear organization and transcriptional silencing in yeast.PMID 8988257Read ↗

The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae.Semantic proximity Read ↗

Yeast silent mating type loci form heterochromatic clusters through silencer protein-dependent long-range interactions.Semantic proximity Read ↗

SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres.Semantic proximity Read ↗

SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast.Semantic proximity Read ↗

Tethered Sir3p nucleates silencing at telomeres and internal loci in Saccharomyces cerevisiae.Semantic proximity Read ↗

Spreading of transcriptional repressor SIR3 from telomeric heterochromatin.Semantic proximity Read ↗

Live imaging of telomeres: yKu and Sir proteins define redundant telomere-anchoring pathways in yeast.Semantic proximity Read ↗

Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing.Semantic proximity Read ↗

The positioning of yeast telomeres depends on SIR3, SIR4, and the integrity of the nuclear membrane.Semantic proximity Read ↗

Regulation of nuclear positioning and dynamics of the silent mating type loci by the yeast Ku70/Ku80 complex.Semantic proximity Read ↗

Heterochromatin organization of a natural yeast telomere. Recruitment of Sir3p through interaction with histone H4 N terminus is required for the establishment of repressive structures.Semantic proximity Read ↗

A region of the nucleosome required for multiple types of transcriptional silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

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